Description

D-Alanine-3,3,3-D3 CAS NO 177614-69-6 is a stable isotope-labeled analog of the non-essential amino acid D-alanine, specifically deuterated at the three methyl hydrogens. This compound is a critical tool for advanced research and development, enabling precise metabolic and pharmacokinetic studies through mass spectrometry and NMR spectroscopy. It is primarily required by pharmaceutical R&D laboratories, academic research institutions, and specialized manufacturers of diagnostic reagents and labeled standards.

Application

• Internal Standard for Mass Spectrometry (MS): Used as a quantitative reference standard in LC-MS and GC-MS analyses for accurate measurement of endogenous D-alanine levels in complex biological matrices.
• Metabolic Pathway Tracing: Employed in tracer studies to investigate bacterial cell wall biosynthesis, alanine metabolism, and other biochemical pathways without signal interference from endogenous compounds.
• Pharmaceutical Research: Facilitates drug metabolism and pharmacokinetic (DMPK) studies for compounds involving alanine pathways, improving the accuracy of ADME data.
• NMR Spectroscopy: Serves as a probe in nuclear magnetic resonance studies to elucidate molecular structure, dynamics, and interactions due to the distinct properties of deuterium.
• Diagnostic Kit Manufacturing: Incorporated as a key component in the production of high-precision in-vitro diagnostic (IVD) kits and calibrators.
• Microbiological Research: Used in studies of bacterial physiology, particularly concerning D-alanine's role in peptidoglycan synthesis and antibiotic resistance mechanisms.

Basic Information

Product Name	D-Alanine-3,3,3-D3
CAS No.	177614-69-6
Molecular Formula	C3D3H4NO2
Molecular Weight	92.11 g/mol
Synonyms	(2R)-2-Aminopropanoic-3,3,3-d3 Acid; D-α-Alanine-3,3,3-d3; Deuterated D-Alanine; D-Alanine-d3; (R)-Alanine-3,3,3-d3; (R)-2-Aminopropionic-3,3,3-d3 Acid; D-Alanine (methyl-d3); D-ALA-d3
EINECS	Contact for details

Quality Control

Our D-Alanine-3,3,3-D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and MS, to verify chemical purity, isotopic enrichment (typically >98 atom % D), and chiral purity. Certificates of Analysis (COA) detailing all specifications are provided and traceable to relevant standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccated or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.