Description

1-Boc-2,3-Dihydro-Indole-3-Carboxylic Acid is a protected indole derivative that serves as a crucial chiral building block in advanced organic synthesis. Its value lies in providing a versatile scaffold for constructing complex molecules with precise stereochemistry. This high-purity intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel drug candidates, especially in central nervous system (CNS) and oncology research.
• Peptidomimetic Synthesis: Used to incorporate constrained, non-natural amino acid motifs into peptide analogs to enhance stability and bioavailability.
• Asymmetric Catalysis Substrate: Serves as a substrate for testing and developing new chiral catalysts and synthetic methodologies.
• Agrochemical Research: Building block for creating new herbicides, fungicides, and insecticides with specific stereochemical requirements.
• Material Science Precursor: Potential intermediate for synthesizing specialty polymers and organic electronic materials with indole-based architectures.

Basic Information

Product Name	1-Boc-2,3-Dihydro-Indole-3-Carboxylic Acid
CAS No.	177201-79-5
Molecular Formula	C14H17NO4
Molecular Weight	263.29 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-2,3-dihydro-1H-indole-3-carboxylic Acid; 1-Boc-indoline-3-carboxylic Acid; 3-Carboxy-1-Boc-indoline; tert-Butyl 3-carboxy-2,3-dihydro-1H-indole-1-carboxylate; 1-N-Boc-2,3-dihydroindole-3-carboxylic Acid; BOC-Indoline-3-COOH; 1-Boc-indoline-3-COOH
EINECS	Contact for details

Quality Control

Our production of 1-Boc-2,3-Dihydro-Indole-3-Carboxylic Acid adheres to stringent in-process controls to ensure batch-to-batch consistency and high chemical purity. Every lot is fully characterized and meets rigorous internal specifications suitable for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), chiral purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.