Description

Dihydro Artemisinin-D3 is a deuterium-labeled derivative of the potent antimalarial compound, dihydroartemisinin. This stable isotope-labeled analog is a critical tool in pharmaceutical research and development, enabling precise pharmacokinetic and metabolic studies. It is primarily utilized by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in drug discovery and development for tropical diseases.

Application

• Internal Standard for Bioanalytical Assays: Serves as a critical reference standard in LC-MS/MS methods for the accurate quantification of dihydroartemisinin and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of artemisinin-based therapies.
• Metabolite Identification and Profiling: Facilitates the structural elucidation of metabolites generated during in vitro and in vivo studies.
• Stable Isotope Dilution Analysis: Enhances the accuracy and precision of quantitative analyses in complex samples, improving data reliability for regulatory submissions.
• Pharmaceutical Reference Standard: Provides a certified material for method validation, quality control, and regulatory compliance in API and formulation development.

Basic Information

Item	Detail
Product Name	Dihydro Artemisinin-D3
CAS No.	176774-98-4
Molecular Formula	C15H21D3O5
Molecular Weight	287.36 g/mol
Synonyms	Dihydroartemisinin-d3; Dihydroqinghaosu-d3; Arteannuin-d3; (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one-d3; Arthemeter Impurity D-d3; Artemisinin Derivative-d3; DHA-d3
EINECS	Contact for details

Quality Control

Every batch of Dihydro Artemisinin-D3 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data including isotopic purity (D-enrichment) and chemical purity determined by advanced chromatographic and spectroscopic methods. A detailed Certificate of Analysis (COA) is supplied with each shipment, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term storage, consider storing at 2-8°C under inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0% (Chemical Purity)
Isotopic Purity (MS)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 99.0% (Area %)
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.