Description

(R)-n-1-Azabicyclo[2.2.2]Oct-3-Yl-6-Chloro-1-(1-Methylethyl)-1H-Benzimidazole-4-Carboxamide Dihydrochloride is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel therapeutic agents, particularly in the field of central nervous system (CNS) research. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new drug candidates.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting neurological receptors.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities.
• Preclinical Studies: Serves as a reference standard or starting material for in-vitro and in-vivo pharmacological testing.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Process Chemistry: Utilized in route scouting and optimization for scalable API manufacturing processes.

Basic Information

Product Name	(R)-n-1-Azabicyclo[2.2.2]Oct-3-Yl-6-Chloro-1-(1-Methylethyl)-1H-Benzimidazole-4-Carboxamide Dihydrochloride
CAS No.	175729-69-8
Molecular Formula	C19H25ClN4O • 2HCl
Molecular Weight	437.80 g/mol (as dihydrochloride salt)
Synonyms	(R)-6-Chloro-1-isopropyl-4-(quinuclidin-3-ylcarbamoyl)-1H-benzimidazole dihydrochloride; (R)-3-[(6-Chloro-1-isopropyl-1H-benzimidazol-4-yl)carbonyl]aminoquinuclidine dihydrochloride; Quinuclidine-3-carboxamide, N-(6-chloro-1-(1-methylethyl)-1H-benzimidazol-4-yl)-, (3R)-, dihydrochloride; 175729-69-8; (R)-QNB Dihydrochloride; (R)-QNB 2HCl
EINECS	Contact for details

Quality Control

Our (R)-n-1-Azabicyclo[2.2.2]Oct-3-Yl-6-Chloro-1-(1-Methylethyl)-1H-Benzimidazole-4-Carboxamide Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.