Description

2,5-Piperazinedione,3-(1-Mercapto-1-Methylethyl)-,(S)-(9Ci) is a specialized chiral piperazinedione derivative featuring a protected mercapto functional group, making it a valuable synthetic intermediate. This compound is critical for the development of novel pharmaceuticals and bioactive molecules, particularly in the synthesis of complex peptidomimetics and enzyme inhibitors. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced medicinal chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting protease-related pathways.
• Peptidomimetic Research: Used in the design and construction of peptidomimetic compounds to enhance metabolic stability and bioavailability.
• Chemical Biology Probes: Serves as a precursor for developing activity-based probes to study enzyme function and mechanism.
• Asymmetric Synthesis: The chiral (S)-configuration makes it a valuable starting material for stereoselective synthesis in organic chemistry.
• Ligand Development: Potential use in creating novel chelating agents or ligands for catalysis based on its unique dione and thiol-protected structure.

Basic Information

Product Name	2,5-Piperazinedione,3-(1-Mercapto-1-Methylethyl)-,(S)-(9Ci)
CAS No.	175694-44-7
Molecular Formula	C7H12N2O2S
Molecular Weight	188.25 g/mol
Synonyms	(S)-3-(1-Mercapto-1-methylethyl)piperazine-2,5-dione; (S)-3-(2-Mercaptopropan-2-yl)piperazine-2,5-dione; 3-(1-Mercapto-1-methylethyl)-2,5-piperazinedione, (S)-; 2,5-Diketopiperazine derivative; DKP derivative; Chiral piperazinedione; Thiol-protected diketopiperazine
EINECS	Contact for details

Quality Control

Our 2,5-Piperazinedione,3-(1-Mercapto-1-Methylethyl)-,(S)-(9Ci) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation of the mercapto group. The container should be kept in a cool, dry, and well-ventilated area, separate from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.