Description

Bicyclo[2.2.1]Heptane-1-Carboxylic Acid, 2-Amino- (9Ci) is a specialized chiral building block featuring a rigid norbornane skeleton with both carboxylic acid and amino functional groups. This compound matters for its unique three-dimensional structure, which is highly valuable for imparting specific conformational constraints in advanced molecular design. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, asymmetric synthesis, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Agrochemical Development: Used in creating advanced pesticides and herbicides where a rigid, three-dimensional scaffold can enhance target specificity and environmental stability.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing chiral ligands and organocatalysts used in enantioselective transformations.
• Material Science Research: Employed in the development of specialty polymers and advanced materials with tailored mechanical or optical properties.
• Peptidomimetics & Conformational Studies: The norbornane core is utilized to create constrained peptide analogs for studying protein-protein interactions and improving metabolic stability.

Basic Information

Product Name	Bicyclo[2.2.1]Heptane-1-Carboxylic Acid, 2-Amino- (9Ci)
CAS No.	175428-79-2
Molecular Formula	C8H13NO2
Molecular Weight	155.19 g/mol
Synonyms	2-Aminonorbornane-1-carboxylic acid; 2-Aminobicyclo[2.2.1]heptane-1-carboxylic acid; 1-Amino-2-carboxynorbornane; endo-2-Aminobicyclo[2.2.1]heptane-1-carboxylic acid; 2-Amino-1-norbornanecarboxylic acid; (1R,2S,4R)-2-Aminobicyclo[2.2.1]heptane-1-carboxylic acid (for specific enantiomer); 2-ABCA
EINECS	Contact for details

Quality Control

Our Bicyclo[2.2.1]Heptane-1-Carboxylic Acid, 2-Amino- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay, enantiomeric excess (where applicable), and impurity profiles are available upon request. We adhere to cGMP principles for production relevant to pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.