Description

2-Chloro-4-Fluorothiophenol is a versatile organosulfur building block characterized by its reactive thiol (-SH) group and halogen substituents. This compound matters for its role as a key intermediate in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing sulfur-containing heterocycles and functionalized aromatic systems.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing benzothiophene or thioether motifs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the thiophenol moiety imparts specific biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the development of organic electronic materials, polymers, and liquid crystals due to its aromatic and sulfur-based functionality.
• Chemical Derivatization: Useful for introducing sulfur and halogen functionalities into larger molecular architectures via nucleophilic aromatic substitution or coupling reactions.

Basic Information

Product Name	2-Chloro-4-Fluorothiophenol
CAS No.	175277-99-3
Molecular Formula	C6H4ClFS
Molecular Weight	162.61 g/mol
Synonyms	2-Chloro-4-fluorobenzenethiol; 2-Chloro-4-fluorothiophenol; 1-Chloro-3-fluoro-4-mercaptobenzene; 4-Fluoro-2-chlorothiophenol; 2-Chloro-4-fluorophenyl mercaptan; Benzenethiol, 2-chloro-4-fluoro-; (2-Chloro-4-fluorophenyl)thiol
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Fluorothiophenol is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chromatographic purity analysis and identity confirmation, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity, keep away from oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.