Description

Ethyl 4-Methyl-2-[4-(Trifluoromethyl)Phenyl]-1,3-Thiazole-5-Carboxylate is a high-value, synthetically versatile organic intermediate characterized by its thiazole core and trifluoromethylphenyl substituent. This compound matters for its role as a critical building block in the development of advanced materials and active pharmaceutical ingredients (APIs), where its unique structure imparts desirable properties. It is needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for synthesizing novel compounds with enhanced biological activity and material characteristics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antimicrobials.
• Agrochemical Research: Used in developing next-generation pesticides and herbicides, where the trifluoromethyl group can improve metabolic stability and bioavailability.
• Material Science: Serves as a monomer or additive in the creation of specialty polymers, liquid crystals, and organic electronic materials due to its aromatic and heterocyclic structure.
• Chemical Synthesis: Acts as a versatile scaffold for further functionalization in medicinal and combinatorial chemistry, enabling the creation of diverse chemical libraries.
• Fluorinated Compound Production: Utilized as a source of the trifluoromethylphenyl moiety for introducing fluorine atoms into target molecules, a common strategy in modern drug design.

Basic Information

Product Name	Ethyl 4-Methyl-2-[4-(Trifluoromethyl)Phenyl]-1,3-Thiazole-5-Carboxylate
CAS No.	175277-03-9
Molecular Formula	C14H12F3NO2S
Molecular Weight	315.31 g/mol
Synonyms	Ethyl 4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylate; 5-Carbethoxy-4-methyl-2-(4-trifluoromethylphenyl)thiazole; 2-(4-Trifluoromethylphenyl)-4-methyl-5-ethoxycarbonylthiazole; Ethyl 4-methyl-2-(4-trifluoromethylphenyl)thiazole-5-carboxylate; 1,3-Thiazole-5-carboxylic acid, 4-methyl-2-[4-(trifluoromethyl)phenyl]-, ethyl ester; CAS 175277-03-9; 4-Methyl-2-(4-trifluoromethylphenyl)thiazole-5-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 4-Methyl-2-[4-(Trifluoromethyl)Phenyl]-1,3-Thiazole-5-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) detailing purity, impurities, and full characterization data are provided with each shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.