Description

Methyl 5-Chlorosulfonyl-4-Methoxythiophene-3-Carboxylate is a high-value, multi-functional heterocyclic building block. Its unique structure, featuring both a chlorosulfonyl and a methoxycarbonyl group on a thiophene core, makes it a critical intermediate for synthesizing complex molecules. This compound is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries seeking to introduce specific functional handles for further derivatization.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the thiophene moiety contributes to biological activity.
• Material Science Research: Serves as a monomer or functionalizing agent for creating advanced polymers and organic electronic materials with tailored properties.
• Dye and Pigment Chemistry: Acts as an intermediate for synthesizing specialized heterocyclic dyes and pigments.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.
• Chemical Biology Probes: Utilized in the creation of molecular probes and labeled compounds for biochemical and diagnostic research applications.

Basic Information

Item	Details
Product Name	Methyl 5-Chlorosulfonyl-4-Methoxythiophene-3-Carboxylate
CAS No.	175203-45-9
Molecular Formula	C7H7ClO5S2
Molecular Weight	270.71 g/mol
Synonyms	5-(Chlorosulfonyl)-4-methoxy-3-thiophenecarboxylic acid methyl ester; Methyl 4-methoxy-5-sulfonylchloridethiophene-3-carboxylate; 4-Methoxy-5-chlorosulfonylthiophene-3-carboxylic acid methyl ester; 3-Thiophenecarboxylic acid, 5-(chlorosulfonyl)-4-methoxy-, methyl ester; Methyl 4-methoxy-5-chlorosulfonylthiophene-3-carboxylate; 175203-45-9; Methyl 5-chlorosulfonyl-4-methoxythiophene-3-carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 5-Chlorosulfonyl-4-Methoxythiophene-3-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance in cGMP and ISO 9001 environments for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.