Description

Thiophene-2-Sulfonylacetonitrile is a versatile sulfur-containing heterocyclic building block of significant interest in advanced organic synthesis. Its unique molecular architecture, featuring both a sulfonyl and a nitrile group on a thiophene scaffold, makes it a critical intermediate for constructing complex pharmacophores and functional materials. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the development of novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in the development of enzyme inhibitors, receptor modulators, and other bioactive molecules targeting various therapeutic areas.
• Agrochemical Research: Used in the design and synthesis of new herbicides, fungicides, and insecticides, leveraging its heterocyclic structure for enhanced biological activity.
• Material Science Precursor: Serves as a building block for functional polymers, conductive materials, and organic electronic components due to the electron-withdrawing properties of the sulfonyl and nitrile groups.
• Chemical Synthesis Reagent: Employed in palladium-catalyzed cross-coupling reactions, nucleophilic substitutions, and cyclization reactions to introduce the thiophene-sulfonylacetonitrile moiety into more complex structures.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands for metal catalysis or as a precursor for catalyst frameworks in asymmetric synthesis.

Basic Information

Item	Detail
Product Name	Thiophene-2-Sulfonylacetonitrile
CAS No.	175137-62-9
Molecular Formula	C6H5NO2S2
Molecular Weight	187.24 g/mol
Synonyms	2-(Thiophene-2-sulfonyl)acetonitrile; (Thiophen-2-ylsulfonyl)acetonitrile; Acetonitrile, (2-thienylsulfonyl)-; 2-Thiophenesulfonylacetonitrile; T2SA; TSAN; 2-Thienylsulfonylacetonitrile
EINECS	Contact for details

Quality Control

Every batch of Thiophene-2-Sulfonylacetonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, and custom purity grades or analytical packages are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.