Description

3-Amino-2-Cyano-5-(4-Fluorophenyl)Thiophene is a high-value, multi-functional heterocyclic building block characterized by its amino, cyano, and fluorophenyl substituents. This compound is essential for advanced organic synthesis, enabling the construction of complex molecular architectures with tailored electronic and biological properties. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in drug discovery and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the fluorine atom enhances biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or building block for the development of organic semiconductors, conductive polymers, and non-linear optical (NLO) materials.
• Dye and Pigment Chemistry: Employed in the synthesis of specialized dyes and pigments due to the electron-rich thiophene core and functional handles for modification.
• Chemical Biology Probes: Utilized as a scaffold for creating fluorescent tags or molecular probes to study biological processes.
• Academic & Industrial R&D: A versatile reagent for methodological development in organic chemistry and for exploring new reaction pathways.

Basic Information

Product Name	3-Amino-2-Cyano-5-(4-Fluorophenyl)Thiophene
CAS No.	175137-39-0
Molecular Formula	C11H7FN2S
Molecular Weight	218.25 g/mol
Synonyms	5-(4-Fluorophenyl)-3-amino-2-thiophenecarbonitrile; 3-Amino-5-(4-fluorophenyl)thiophene-2-carbonitrile; 2-Cyano-3-amino-5-(4-fluorophenyl)thiophene; 5-(4-Fluorophenyl)-3-aminothiophene-2-carbonitrile; 3-Amino-2-cyano-5-(p-fluorophenyl)thiophene; 2-Thiophenecarbonitrile, 3-amino-5-(4-fluorophenyl)-; 175137-39-0
EINECS	Contact for details

Quality Control

Our production of 3-Amino-2-Cyano-5-(4-Fluorophenyl)Thiophene adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including HPLC, GC, NMR, and MS for comprehensive characterization and impurity profiling. A Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with every shipment, supporting compliance in cGMP-aligned environments for pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to brown crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.