Description

(S)-A-Hydroxy-3-Thiopheneacetonitrile is a high-value, chiral intermediate characterized by its thiophene ring and nitrile functionality. This compound matters for its role as a critical building block in the synthesis of complex, biologically active molecules, enabling precise stereochemical control. It is primarily needed by pharmaceutical and agrochemical R&D teams for developing new active ingredients, as well as by fine chemical manufacturers specializing in custom synthesis and contract research.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring specific stereochemistry.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where the thiophene moiety contributes to biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or building block for conductive polymers and advanced organic electronic materials due to the thiophene unit.
• Custom Synthesis and CRO: Employed by contract research organizations (CROs) and fine chemical companies for bespoke synthesis projects and process development.

Basic Information

Product Name	(S)-A-Hydroxy-3-Thiopheneacetonitrile
CAS No.	174754-56-4
Molecular Formula	C7H7NOS
Molecular Weight	153.20 g/mol
Synonyms	(S)-2-Hydroxy-2-(thiophen-3-yl)acetonitrile; (S)-α-Hydroxy-3-thiopheneacetonitrile; (S)-Hydroxy(thiophen-3-yl)acetonitrile; 3-Thiopheneacetonitrile, α-hydroxy-, (S)-; (S)-2-Hydroxy-2-(3-thienyl)ethanenitrile; (S)-3-Thienylglycolonitrile; (S)-TGA
EINECS	Contact for details

Quality Control

Our (S)-A-Hydroxy-3-Thiopheneacetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with exacting standards for fine chemical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if necessary to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.