Description

2-Thiophenecarbonitrile, 5-Ethynyl- (9Ci) is a high-value, functionalized heterocyclic building block, specifically a thiophene derivative bearing both cyano and ethynyl substituents. This compound is of significant interest for its role in advanced organic synthesis and materials science, enabling the construction of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries for applications such as click chemistry, cross-coupling reactions, and the synthesis of novel conjugated polymers.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the development of active pharmaceutical ingredients (APIs), particularly for molecules incorporating thiophene scaffolds.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides that require specific heterocyclic frameworks for bioactivity.
• Material Science & Organic Electronics: A crucial monomer for constructing conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), and field-effect transistors (OFETs).
• Click Chemistry Reagent: The terminal alkyne group enables efficient Huisgen 1,3-dipolar cycloaddition (copper-catalyzed azide-alkyne cycloaddition, CuAAC) for bioconjugation and polymer functionalization.
• Cross-Coupling Reactions: Acts as a substrate in Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions to form complex carbon-carbon bonds.
• Ligand Synthesis: Used to prepare novel ligands for catalysis, leveraging the coordinating potential of the thiophene and nitrile functionalities.

Basic Information

Product Name	2-Thiophenecarbonitrile, 5-Ethynyl- (9Ci)
CAS No.	174672-60-7
Molecular Formula	C7H3NS
Molecular Weight	133.17 g/mol
Synonyms	5-Ethynyl-2-thiophenecarbonitrile; 5-Ethynylthiophene-2-carbonitrile; 2-Cyano-5-ethynylthiophene; 5-Ethynylthiophene-2-carbonitrile; (5-Ethynyl-2-thienyl)carbonitrile; 2-Thiophenecarbonitrile, 5-ethynyl-; 5-Ethynyl-2-thiophenenitrile
EINECS	Contact for details

Quality Control

Our 2-Thiophenecarbonitrile, 5-Ethynyl- (9Ci) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our commitment to quality supports research and development requiring high-purity building blocks for reliable and reproducible results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.