Description

Trichloroacetic-1-13C Acid CAS NO 173470-69-4 is a stable isotope-labeled derivative of trichloroacetic acid, where one carbon atom is replaced with the carbon-13 (13C) isotope. This precise labeling is critical for applications requiring high sensitivity and accurate quantification, such as mass spectrometry-based analysis. It is an essential reagent for researchers and quality control laboratories in the pharmaceutical, agrochemical, and environmental science sectors who utilize isotope dilution methods for precise measurement of metabolites, impurities, and environmental contaminants.

Application

• Internal Standard for Quantitative Mass Spectrometry (MS): Serves as a critical internal standard in LC-MS and GC-MS analyses for the accurate quantification of trichloroacetic acid and related compounds, minimizing matrix effects.
• Metabolite Tracing & Pharmacokinetic Studies: Used in drug metabolism and disposition (DMPK) studies to trace the metabolic pathways of pharmaceuticals and agrochemicals containing trichloroacetyl moieties.
• Environmental & Food Safety Analysis: Enables precise monitoring of trichloroacetic acid, a disinfection byproduct and environmental pollutant, in water, food, and biological samples.
• Proteomics & Biochemistry Research: Employed in protein precipitation procedures and as a reagent in biochemical studies where isotopic labeling is required for mechanistic insights.
• Nuclear Magnetic Resonance (NMR) Spectroscopy: Acts as a 13C-labeled standard or reagent for NMR spectroscopic analysis and method development.
• Synthesis of Labeled Compounds: Used as a labeled building block for the synthesis of more complex 13C-labeled intermediates and active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Trichloroacetic-1-13C Acid
CAS No.	173470-69-4
Molecular Formula	C13CCl3O2H or CCl313COOH
Molecular Weight	164.37 g/mol (approx.)
Synonyms	Trichloroacetic-1-13C Acid; [1-13C]-Trichloroacetic Acid; 13C-Labeled Trichloroacetic Acid; TCA-13C; Carbon-13 Labeled Trichloroacetic Acid; Isotopic Trichloroacetic Acid; Trichloro(13C)acetic Acid
EINECS	Contact for details

Quality Control

Our Trichloroacetic-1-13C Acid is manufactured under strict quality control protocols to ensure exceptional isotopic and chemical purity, which is paramount for analytical accuracy. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment, chemical purity (by HPLC/NMR), and impurity profile. We adhere to relevant industry standards for stable isotope-labeled compounds to guarantee reliable and reproducible performance in your sensitive applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and a strong acid/organic solvent; ensure containers are sealed immediately after use to prevent moisture absorption and degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR / NMR)	Conforms to structure
Isotopic Enrichment	≥ 99 atom % 13C
Chemical Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.