Description

tert-Butyl 2-(Hydroxymethyl)-1-Indolinecarboxylate is a high-purity, protected indoline derivative serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a versatile scaffold for constructing complex nitrogen-containing heterocycles, which are central to modern pharmaceutical discovery. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop novel active ingredients.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of bioactive molecules, including potential kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Research: Building block for developing novel herbicides, fungicides, and insecticides with complex heterocyclic structures.
• Fine Chemical Synthesis: Used in the preparation of specialty chemicals, ligands for catalysis, and advanced materials.
• Academic & R&D: A valuable reagent for methodological studies in asymmetric synthesis and heterocyclic chemistry within university and corporate research laboratories.
• Peptidomimetics: Serves as a constrained proline analog or scaffold in the design of peptide-like molecules with enhanced metabolic stability.

Basic Information

Product Name	tert-Butyl 2-(Hydroxymethyl)-1-Indolinecarboxylate
CAS No.	172647-87-9
Molecular Formula	C14H19NO3
Molecular Weight	249.31 g/mol
Synonyms	1-Boc-2-(hydroxymethyl)indoline; 2-(Hydroxymethyl)indoline-1-carboxylic acid tert-butyl ester; tert-Butyl 2-(hydroxymethyl)indoline-1-carboxylate; 1-(tert-Butoxycarbonyl)-2-(hydroxymethyl)indoline; 2-Hydroxymethyl-N-Boc-indoline; N-Boc-2-(hydroxymethyl)indoline; Boc-2-(hydroxymethyl)indoline; 172647-87-9
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(Hydroxymethyl)-1-Indolinecarboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for research and process chemistry. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformity to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.