Description

L-n-Valyl-L-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid Benzyl Ester Hcl is a high-purity, protected dipeptide building block essential for advanced peptide synthesis. This compound is valued for its role in constructing complex peptide sequences with specific structural motifs, enabling research and development in targeted therapeutic areas. It is a critical intermediate for pharmaceutical researchers and fine chemical manufacturers working on novel drug candidates, particularly in the fields of oncology and neurology.

Application

• Pharmaceutical Intermediate: A key building block in the solid-phase and solution-phase synthesis of complex therapeutic peptides.
• Peptidomimetic Research: Used to incorporate the 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) scaffold, a non-natural amino acid analog, into novel drug candidates.
• Protease Inhibitor Development: Serves as a precursor in the synthesis of inhibitors targeting specific enzymes like renin or HIV protease.
• Chemical Biology Probes: Employed in the creation of labeled or modified peptides for studying protein-protein interactions and cellular pathways.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse peptide libraries for high-throughput screening in drug discovery.
• Academic & Contract Research: Supports fundamental research in medicinal chemistry and peptide science at universities and CROs.

Basic Information

Product Name	L-n-Valyl-L-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid Benzyl Ester Hcl
CAS No.	172499-31-9
Molecular Formula	C24H29N3O4 • HCl
Molecular Weight	459.97 g/mol
Synonyms	Boc-Val-Tic-OBzl HCl; N-(tert-Butoxycarbonyl)-L-valyl-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid benzyl ester hydrochloride; L-Valyl-L-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid, N-[(1,1-dimethylethoxy)carbonyl]-, phenylmethyl ester, hydrochloride; Benzyl N-[(2S)-1-[[(2S)-1-(benzyloxy)-1-oxo-3,4-dihydro-2H-isoquinoline-3-carbonyl]amino]-3-methylbutan-2-yl]carbamate hydrochloride; Val-Tic-OBzl HCl; Boc-Val-Tic(OBzl)-OH.HCl
EINECS	Contact for details

Quality Control

Our L-n-Valyl-L-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid Benzyl Ester Hcl is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (HPLC, Total)	≥99.0%
Single Maximum Impurity	≤1.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.