Description

5-(Hydroxymethyl)Thiophene-2-Carbonitrile is a versatile heterocyclic building block featuring both a hydroxymethyl and a nitrile functional group on a thiophene core. This compound is of significant value in advanced organic synthesis, particularly for constructing complex molecules in the pharmaceutical and agrochemical sectors. It is primarily sought after by research chemists and process development scientists for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging the thiophene scaffold's bioactivity.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of conductive polymers, organic semiconductors, and advanced organic frameworks.
• Ligand and Catalyst Development: The functional groups allow for derivatization into chelating ligands for metal catalysis or organocatalysts.
• Fine Chemical Manufacturing: Employed in custom synthesis and contract manufacturing for producing specialty chemicals with specific electronic or steric properties.

Basic Information

Product Name	5-(Hydroxymethyl)Thiophene-2-Carbonitrile
CAS No.	172349-09-6
Molecular Formula	C6H5NOS
Molecular Weight	139.17 g/mol
Synonyms	2-Cyano-5-hydroxymethylthiophene; (5-Hydroxymethyl-2-thienyl)acetonitrile; 5-Hydroxymethyl-2-thiophenecarbonitrile; 2-Thiophenecarbonitrile, 5-(hydroxymethyl)-; Thiophene-2-carbonitrile, 5-(hydroxymethyl)-; 5-(Hydroxymethyl)-2-thiophenecarbonitrile; 5-(Hydroxymethyl)thiophene-2-carbonitrile
EINECS	Contact for details

Quality Control

Our 5-(Hydroxymethyl)Thiophene-2-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.