Description

tert-Butyl 2-(2-Ethoxy-2-Oxoethyl)-1H-Indole-1-Carboxylate is a high-purity, protected indole derivative that serves as a critical synthetic intermediate in advanced organic synthesis. Its value lies in the dual protection of the indole nitrogen and the activated ethyl ester side chain, enabling precise, multi-step reactions for constructing complex heterocyclic systems. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries who require reliable building blocks for drug discovery and active ingredient synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel indole-based active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and development of new generation pesticides and herbicides that leverage the indole scaffold for bioactivity.
• Organic Synthesis Reagent: Serves as a versatile precursor for palladium-catalyzed cross-coupling reactions, such as Heck or Suzuki reactions, to create complex molecular architectures.
• Material Science Research: Employed in the development of organic electronic materials and functional dyes where the indole core contributes to photophysical properties.
• Academic & R&D Laboratories: A valuable tool for methodological studies in synthetic organic chemistry and for exploring new reaction pathways.

Basic Information

Product Name	tert-Butyl 2-(2-Ethoxy-2-Oxoethyl)-1H-Indole-1-Carboxylate
CAS No.	172226-77-6
Molecular Formula	C₁₇H₂₁NO₄
Molecular Weight	303.35 g/mol
Synonyms	1-Boc-2-(2-ethoxy-2-oxoethyl)indole; 1-(tert-Butoxycarbonyl)-2-(2-ethoxy-2-oxoethyl)-1H-indole; tert-Butyl 2-(carbethoxymethyl)indole-1-carboxylate; 2-(2-Ethoxy-2-oxoethyl)-1H-indole-1-carboxylic acid tert-butyl ester; 1H-Indole-1-carboxylic acid, 2-(2-ethoxy-2-oxoethyl)-, 1,1-dimethylethyl ester; Boc-2-CH2CO2Et-indole; 172226-77-6
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(2-Ethoxy-2-Oxoethyl)-1H-Indole-1-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and scale-up. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.