Description

Acrivastine D7 is a deuterated analog of the antihistamine drug substance, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity, isotopically labeled compound is essential for ensuring the accuracy and reliability of mass spectrometry-based analyses in pharmaceutical research and development. It is primarily utilized by analytical chemists and quality control laboratories in the pharmaceutical, contract research organization (CRO), and regulatory testing sectors for precise pharmacokinetic studies, metabolite identification, and bioanalytical method validation.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference compound for the accurate quantification of Acrivastine in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic and Bioavailability Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical trials.
• Metabolite Profiling and Identification: Used as a stable isotope-labeled tracer to distinguish drug-derived metabolites from endogenous compounds in mass spectrometric analysis.
• Method Development and Validation: Provides a stable and consistent signal for establishing calibration curves and assessing the precision, accuracy, and sensitivity of bioanalytical assays.
• Quality Control in Pharmaceutical Manufacturing: Supports impurity profiling and assay verification of Acrivastine in active pharmaceutical ingredient (API) and finished drug product batches.
• Forensic and Doping Control Analysis: Facilitates the definitive identification and quantification of Acrivastine in specialized forensic toxicology or anti-doping testing protocols.

Basic Information

Product Name	Acrivastine D7
CAS No.	172165-56-9
Molecular Formula	C22H17D7N2O2
Molecular Weight	~355.48 g/mol
Synonyms	(E)-3-[6-[(1E)-1-(4-Methylphenyl)-3-pyrrolidin-1-yl-prop-1-enyl]pyridin-2-yl]acrylic acid-d7; Acrivastine-d7; 2-[(E)-3-(6-[(E)-1-(4-Methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridin-2-yl)prop-2-enoyl]oxy-d7-benzoic acid; BW-825C-d7; Duact-d7; Semprex-d7
EINECS	Contact for details

Quality Control

Our Acrivastine D7 is manufactured under strict quality management systems to ensure the highest standards of isotopic purity and chemical integrity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing critical parameters such as isotopic enrichment (Atom % D), chemical purity (by HPLC), and confirmation of structure. We support compliance with cGMP guidelines for research use and provide full traceability for all materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant use and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.