Description

D-Erythro-N,n-Dimethylsphingosine-D6 is a deuterated isotopologue of a key sphingolipid metabolite, specifically designed for use as an internal standard in quantitative bioanalytical research. This high-purity, stable isotope-labeled compound is critical for ensuring accuracy and reproducibility in mass spectrometry-based assays by correcting for analyte loss during sample preparation and instrument variability. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and academic sectors focused on lipidomics, drug metabolism studies, and sphingolipid signaling pathway analysis.

Application

• Quantitative Mass Spectrometry Internal Standard: Primary use as a stable isotope-labeled internal standard for the precise quantification of endogenous N,N-Dimethylsphingosine (DMS) and related sphingolipids in complex biological matrices like plasma, serum, and tissue homogenates.
• Lipidomics Research: Enables accurate profiling and discovery of sphingolipid biomarkers in disease states such as cancer, metabolic disorders, and neurological conditions.
• Pharmacokinetic & Drug Metabolism Studies (PK/PD): Used to track the metabolism and distribution of sphingolipid-based drug candidates or to study drug-induced changes in sphingolipid metabolism.
• Cell Signaling Pathway Analysis: Facilitates research into the role of sphingolipid metabolites like DMS in apoptosis, cell proliferation, and inflammation.
• Diagnostic Assay Development: Serves as a critical reference material in the development and validation of clinical diagnostic tests targeting sphingolipid pathways.
• Quality Control & Method Validation: Essential for ensuring the accuracy, precision, and robustness of analytical methods in contract research organizations (CROs) and pharmaceutical QC labs.

Basic Information

Product Name	D-Erythro-N,n-Dimethylsphingosine-D6
CAS No.	171827-65-9
Molecular Formula	C20D6H35NO2
Molecular Weight	321.56 g/mol
Synonyms	(2S,3R)-2-(Dimethylamino)-3-hydroxyoctadec-4-yn-1-ol-d6; N,N-Dimethyl-D-erythro-sphingosine-d6; DMS-d6; D-erythro-N,N-Dimethylsphingosine (hexadeuterated); Dimethylsphingosine-d6; DMS(D6); (2S,3R)-2-(N,N-Dimethylamino)-3-hydroxy-1-octadecyn-4-ene-d6; N,N-Dimethylsphingosine-d6 (D-erythro form)
EINECS	Contact for details

Quality Control

Our D-Erythro-N,n-Dimethylsphingosine-D6 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive bioanalytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results from NMR (¹H, ²H, ¹³C), High-Resolution Mass Spectrometry (HRMS), and HPLC for chemical and isotopic identity, purity, and assay. We adhere to ISO 9001 guidelines, and our quality commitment ensures traceability, stability, and consistency for critical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture ingress. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (HRMS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (²H NMR/MS)	≥ 98 atom % D
Chemical Purity (Titration)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.