Description

Folic Acid-D4 is a high-purity, stable isotope-labeled analog of folic acid, specifically deuterated at four positions. This compound is essential as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is critically needed by pharmaceutical R&D laboratories, clinical research organizations, and analytical testing facilities for method development, validation, and precise quantification of folic acid and its metabolites in complex biological matrices.

Application

• Internal Standard for LC-MS/MS and GC-MS analysis of folic acid in pharmacokinetic and bioavailability studies.
• Quantitative reference material in clinical diagnostics for measuring folate levels in serum, plasma, and whole blood.
• Critical reagent in pharmaceutical quality control for the assay of folic acid in finished drug products and nutritional supplements.
• Use in metabolic pathway research and stable isotope tracer studies to investigate folate metabolism and related disorders.
• Calibration standard for ensuring regulatory compliance in food and beverage fortification analysis.
• Tool for environmental and agricultural research analyzing folate content in crops and soils.

Basic Information

Product Name	Folic Acid-D4
CAS No.	171777-72-3
Molecular Formula	C₁₉H₁₅D₄N₇O₆
Molecular Weight	445.41 g/mol
Synonyms	Folic Acid-d4; Vitamin B9-d4; Pteroyl-L-glutamic Acid-d4; (2S)-2-[[4-[[(2-Amino-4-oxo-1H-pteridin-6-yl)methyl-d2]amino-d2]benzoyl]amino]pentanedioic Acid; N-[4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl-d2]amino-d2]benzoyl]-L-glutamic Acid; Folacin-d4; Folvite-d4
EINECS	Contact for details

Quality Control

Every batch of our Folic Acid-D4 (CAS 171777-72-3) is manufactured under strict quality management systems. The product undergoes comprehensive analytical testing, including NMR and Mass Spectrometry, to confirm isotopic enrichment and chemical purity. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes batch-specific data on purity, isotopic purity, and residual solvents. Our quality commitment ensures consistency and reliability for your most demanding analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C under inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.