Description

(6R,Trans)-6-(3,4-Dihydroxyphenyl)-2,3,6,7,12,12A-Hexahydro-2-Methyl-Pyrazino[1',2':1,6]Pyrido[3,4-B]Indole-1,4-Dione is a high-purity, complex heterocyclic compound of significant interest in advanced pharmaceutical research and development. This molecule serves as a critical intermediate or reference standard for the synthesis and study of novel therapeutic agents targeting neurological and cardiovascular systems. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in cutting-edge drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex alkaloid-derived drug candidates.
• Neurological Research: Used as a reference compound in studies targeting neurodegenerative diseases and CNS disorders.
• Cardiovascular Drug Development: Serves as a precursor or analog in the research of vasodilatory or cardioprotective agents.
• Enzyme Inhibition Studies: Potential use as a ligand or inhibitor in biochemical assays for specific enzymatic targets.
• Reference Standard: High-purity material for analytical method development, validation, and quality control in pharmaceutical analysis.
• Academic & Institutional Research: Utilized in universities and research institutes for chemical biology and medicinal chemistry projects.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of advanced pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	(6R,Trans)-6-(3,4-Dihydroxyphenyl)-2,3,6,7,12,12A-Hexahydro-2-Methyl-Pyrazino[1',2':1,6]Pyrido[3,4-B]Indole-1,4-Dione
CAS No.	171489-03-5
Molecular Formula	C22H19N3O4
Molecular Weight	389.41 g/mol
Synonyms	6R-Trans-6-(3,4-Dihydroxyphenyl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione; (6R,12aR)-6-(3,4-Dihydroxyphenyl)-2-methyl-1,4,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione; Tetrahydroprotoberberine derivative; Isoquinoline alkaloid analog; Pyrazinopyridoindoledione
EINECS	Contact for details

Quality Control

Our (6R,Trans)-6-(3,4-Dihydroxyphenyl)-2,3,6,7,12,12A-Hexahydro-2-Methyl-Pyrazino[1',2':1,6]Pyrido[3,4-B]Indole-1,4-Dione is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant ICH guidelines for stability and impurity characterization to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.