Description

2-Azabicyclo[2.2.0]Hex-5-En-3-One,2-(Hydroxymethyl)-,(1S)-(9Ci) is a high-value, chiral bicyclic lactam building block of significant interest in advanced organic synthesis. This compound matters because its unique, strained scaffold and functional handles enable the efficient construction of complex, nitrogen-containing molecular architectures. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel protease inhibitors, enzyme modulators, and other bioactive molecules.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides with specific stereochemical requirements.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing novel chiral ligands and organocatalysts.
• Natural Product & Alkaloid Synthesis: Facilitates the construction of complex, bridged bicyclic core structures found in many natural products.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers with unique thermal or mechanical properties.
• Academic & Contract Research: Employed in methodological studies and discovery chemistry within university and CRO laboratories.

Basic Information

Product Name	2-Azabicyclo[2.2.0]Hex-5-En-3-One,2-(Hydroxymethyl)-,(1S)-(9Ci)
CAS No.	171228-86-7
Molecular Formula	C7H9NO2
Molecular Weight	139.15 g/mol
Synonyms	(1S)-2-(Hydroxymethyl)-2-azabicyclo[2.2.0]hex-5-en-3-one; (1S)-2-(Hydroxymethyl)-2-azabicyclo[2.2.0]hex-5-en-3-one (9CI); 2-Azabicyclo[2.2.0]hex-5-en-3-one, 2-(hydroxymethyl)-, (1S)-; (S)-2-(Hydroxymethyl)-2-azabicyclo[2.2.0]hex-5-en-3-one; Chiral Bicyclic Lactam; 2-Azabicyclo[2.2.0]hex-5-ene-3-one, 2-(hydroxymethyl)-, (1S)-; (1S)-2-(Hydroxymethyl)-2-azabicyclo[2.2.0]hex-5-en-3-one, 9CI
EINECS	Contact for details

Quality Control

Our 2-Azabicyclo[2.2.0]Hex-5-En-3-One,2-(Hydroxymethyl)-,(1S)-(9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure high chemical and enantiomeric purity suitable for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.