Description

1,2,3,4-Tetrahydroisoquinoline-6-Carbonitrile Hydrochloride is a high-purity organic salt derivative of the tetrahydroisoquinoline scaffold. This compound serves as a critical pharmaceutical intermediate and research chemical for the synthesis of complex bioactive molecules. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential therapeutic agents, particularly those targeting the central nervous system.
• Alkaloid Synthesis: Used in the preparation of complex tetrahydroisoquinoline-based natural product analogs and derivatives.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Chemical Biology Probes: Employed in the development of molecular probes for studying enzyme function and receptor interactions.
• Process Chemistry: Used in the development and scale-up of synthetic routes for active pharmaceutical ingredients (APIs).
• Academic Research: A valuable reagent for universities and research institutes studying heterocyclic chemistry and organic synthesis methodologies.

Basic Information

Product Name	1,2,3,4-Tetrahydroisoquinoline-6-Carbonitrile Hydrochloride
CAS No.	171084-93-8
Molecular Formula	C₁₀H₁₀N₂·HCl
Molecular Weight	194.66 g/mol
Synonyms	6-Cyano-1,2,3,4-tetrahydroisoquinoline hydrochloride; 1,2,3,4-Tetrahydro-6-cyanoisoquinoline hydrochloride; 1,2,3,4-Tetrahydroisoquinoline-6-carbonitrile HCl; THIQ-6-CN hydrochloride; 6-CN-THIQ HCl; 6-Cyano-THIQ hydrochloride; 1,2,3,4-Tetrahydro-6-isoquinolinecarbonitrile hydrochloride
EINECS	Contact for details

Quality Control

Our 1,2,3,4-Tetrahydroisoquinoline-6-Carbonitrile Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, and we support customer-specific analytical method validations upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.