Description

7-Amino-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid tert-Butyl Ester is a high-purity, protected amino acid derivative serving as a critical chiral building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures with high stereochemical fidelity, enabling the development of novel active pharmaceutical ingredients. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, particularly for the synthesis of isoquinoline-based drug candidates and other bioactive heterocycles.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly those containing the isoquinoline scaffold.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and the synthesis of compound libraries for high-throughput screening.
• Peptidomimetic Synthesis: Serves as a constrained, non-natural amino acid analog for the design and synthesis of peptide-like molecules with enhanced metabolic stability.
• Asymmetric Synthesis: Employed as a building block in stereoselective reactions to introduce chiral centers into complex organic molecules.
• Chemical Biology Probes: Utilized in the synthesis of labeled or tagged molecules for studying biological pathways and target engagement.

Basic Information

Product Name	7-Amino-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid tert-Butyl Ester
CAS No.	171049-41-5
Molecular Formula	C14H18N2O2
Molecular Weight	246.31 g/mol
Synonyms	tert-Butyl 7-amino-3,4-dihydro-1H-isoquinoline-2-carboxylate; 7-Amino-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; 2-tert-Butoxycarbonyl-7-amino-1,2,3,4-tetrahydroisoquinoline; Boc-7-Amino-Tic-OH; 7-Amino-Tic(OtBu)-OH; 7-Amino-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 7-Amino-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.