Description

1H-Indole, 3-Iodo-1-[(4-Methylphenyl)Sulfonyl]- is a high-purity, functionalized indole derivative of significant interest in advanced organic synthesis. This compound matters as a versatile and critical building block for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging the indole core's bioactivity.
• Material Science Precursor: Acts as a monomer or functionalizing agent in the creation of advanced polymers and organic electronic materials.
• Chemical Biology Probe: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create diverse biaryl structures.
• Sulfonamide Library Synthesis: Used in high-throughput screening and combinatorial chemistry to generate libraries of sulfonamide-containing compounds for biological evaluation.

Basic Information

Product Name	1H-Indole, 3-Iodo-1-[(4-Methylphenyl)Sulfonyl]-
CAS No.	170456-80-1
Molecular Formula	C15H12INO2S
Molecular Weight	397.23 g/mol
Synonyms	3-Iodo-1-tosylindole; 1-(4-Methylphenyl)sulfonyl-3-iodo-1H-indole; 3-Iodo-1H-indole, 1-[(4-methylphenyl)sulfonyl]-; 1-Tosyl-3-iodoindole; N-Tosyl-3-iodoindole; 3-Iodo-1-tosyl-1H-indole; 1-(p-Toluenesulfonyl)-3-iodoindole; 3-Iodoindole-1-sulfonic acid 4-methylphenyl ester
EINECS	Contact for details

Quality Control

Our 1H-Indole, 3-Iodo-1-[(4-Methylphenyl)Sulfonyl]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification parameters. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliable supply for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light sources to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.