Description

Ethanone, 2,2,2-Trifluoro-1-(1H-Indol-5-Yl)- (9Ci) is a high-purity trifluoromethyl ketone derivative of indole, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique molecular structure, featuring both an indole scaffold and a reactive trifluoroacetyl group, makes it an indispensable building block for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing complex molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of drug candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and insecticides, where the trifluoromethyl group improves lipophilicity and bioactivity.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of specialty polymers and advanced organic materials.
• Fluorine Chemistry Building Block: Essential for introducing the trifluoroacetyl moiety into complex molecules in medicinal and synthetic chemistry research.
• Biochemical Probe Development: Utilized in creating labeled compounds and probes for biochemical assays and diagnostic research.

Basic Information

Product Name	Ethanone, 2,2,2-Trifluoro-1-(1H-Indol-5-Yl)- (9Ci)
CAS No.	170366-90-2
Molecular Formula	C11H6F3NO
Molecular Weight	225.17 g/mol
Synonyms	5-(2,2,2-Trifluoroacetyl)indole; 1H-Indol-5-yl trifluoromethyl ketone; 2,2,2-Trifluoro-1-(1H-indol-5-yl)ethanone; 5-Trifluoroacetylinodole; 5-(Trifluoroacetyl)-1H-indole; α,α,α-Trifluoro-5-indolyl methyl ketone; 5-Indolyl trifluoromethyl ketone
EINECS	Contact for details

Quality Control

Our Ethanone, 2,2,2-Trifluoro-1-(1H-Indol-5-Yl)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.