Description

n-Boc-5-Hydroxyindoline is a protected indoline derivative, a crucial advanced pharmaceutical intermediate (API) and versatile building block in organic synthesis. Its value lies in the strategic protection of the indoline nitrogen with the tert-butoxycarbonyl (Boc) group, which allows for selective chemical transformations of the aromatic hydroxyl group. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active compounds, particularly in medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in the exploration of structure-activity relationships (SAR) for new therapeutic agents due to its modifiable scaffold.
• Agrochemical Synthesis: Serves as a precursor in the development of new pesticides and herbicides.
• Organic Synthesis Building Block: Employed in multi-step syntheses to construct more complex heterocyclic compounds and natural product analogs.
• Protecting Group Chemistry: Demonstrates the application of Boc-protection strategies for amine functionalities in complex molecule assembly.

Basic Information

Product Name	n-Boc-5-Hydroxyindoline
CAS No.	170147-76-9
Molecular Formula	C₁₃H₁₇NO₃
Molecular Weight	235.28 g/mol
Synonyms	5-Hydroxyindoline-1-carboxylic acid tert-butyl ester; tert-Butyl 5-hydroxy-2,3-dihydro-1H-indole-1-carboxylate; 1-Boc-5-hydroxyindoline; 1-N-Boc-5-hydroxyindoline; 5-Hydroxy-1-N-Boc-indoline; 1-(tert-Butoxycarbonyl)-5-hydroxyindoline; Boc-5-hydroxyindoline
EINECS	Contact for details

Quality Control

Our n-Boc-5-Hydroxyindoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.