Description

2-(tert-Butoxycarbonyl)-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid is a high-purity, protected amino acid derivative serving as a critical building block in advanced organic synthesis. Its primary value lies in enabling the controlled construction of complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially within the fields of central nervous system (CNS) and cardiovascular therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those containing the tetrahydroisoquinoline scaffold.
• Peptide Mimetics & PROTACs: Used to incorporate constrained, rigid structures into peptide backbones and proteolysis-targeting chimeras (PROTACs) for enhanced stability and binding affinity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new chemical entities for various therapeutic targets.
• Process Chemistry & Scale-Up: Serves as a defined starting material for the GMP-compliant manufacturing of active pharmaceutical ingredients (APIs).
• Chemical Biology Probes: Utilized in the development of labeled compounds and probes for studying biological pathways and target engagement.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) engaged in synthetic methodology and novel compound library development.

Basic Information

Product Name	2-(tert-Butoxycarbonyl)-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid
CAS No.	170097-67-3
Molecular Formula	C15H19NO4
Molecular Weight	277.32 g/mol
Synonyms	Boc-Tic-OH; 6-Carboxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; 2-(Boc)-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid; 1,2,3,4-Tetrahydroisoquinoline-6-carboxylic acid, 2-[(1,1-dimethylethoxy)carbonyl]-; 2-N-Boc-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid; Boc-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid; 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydro-6-isoquinolinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 2-(tert-Butoxycarbonyl)-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.