Description

Diphenhydramine-D3 is a stable isotope-labeled analog of the widely used antihistamine, diphenhydramine, where three hydrogen atoms are replaced by deuterium. This compound is essential as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in mass spectrometry-based analyses. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, drug metabolism research, and clinical trial sample analysis.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of diphenhydramine and its metabolites in biological matrices such as plasma, serum, and urine.
• Pharmacokinetic and Bioavailability Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Forensic and Clinical Toxicology: Used in confirmatory testing and method development for the detection of diphenhydramine in forensic and diagnostic applications.
• Drug Metabolism Research: Facilitates the identification and quantification of metabolite profiles to understand biotransformation pathways.
• Method Development and Validation: Serves as a key component in developing and validating robust, GLP-compliant analytical protocols.
• Quality Control in Pharmaceutical Manufacturing: Can be utilized in impurity profiling and stability-indicating assay methods for drug substance and product analysis.

Basic Information

Product Name	Diphenhydramine-D3
CAS No.	170082-18-5
Molecular Formula	C17H18D3NO
Molecular Weight	258.38 g/mol
Synonyms	2-(Diphenylmethoxy)-N,N-dimethylethanamine-D3; Dideuterio(trideuteriomethyl)(2-{phenyl[phenyl-d5]methoxy}ethyl)amine; Benzhydryloxyethyl-dimethylamine-D3; Deuterated Diphenhydramine; Diphenhydramine (phenyl-d5, N,N-dimethyl-d3); DPH-D3; Diphenhydramine-d3 Internal Standard
EINECS	Contact for details

Quality Control

Our Diphenhydramine-D3 is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment, chemical purity, and absence of interfering impurities. We adhere to relevant industry standards for reference materials, and custom purity grades or specific certifications (e.g., for GLP studies) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.