Description

Estazolam-D5 is a deuterated internal standard of the pharmaceutical compound Estazolam, specifically designed for analytical applications. This high-purity, isotopically labeled compound is essential for ensuring accuracy and reliability in quantitative mass spectrometry analysis. It is primarily used by analytical chemists and researchers in pharmaceutical development, forensic toxicology, and clinical research laboratories. The product, identified by CAS No. 170082-16-3, provides a critical tool for method validation and precise measurement.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for the analysis of Estazolam in biological matrices.
• Pharmaceutical Research & Development: Facilitates pharmacokinetic studies, metabolite profiling, and bioanalytical method development for sedative-hypnotic drugs.
• Forensic Toxicology: Enables accurate quantification of Estazolam in post-mortem and human performance testing, supporting legal and medical investigations.
• Clinical Laboratory Testing: Employed in clinical labs for therapeutic drug monitoring (TDM) to ensure proper dosing and patient safety.
• Reference Material for Quality Control: Serves as a certified reference material (CRM) for calibrating instruments and validating analytical procedures in QA/QC laboratories.
• Drug Metabolism Studies: Aids in the identification and quantification of drug metabolites in in vitro and in vivo studies.

Basic Information

Product Name	Estazolam-D5
CAS No.	170082-16-3
Molecular Formula	C16H6D5ClN4
Molecular Weight	299.77 g/mol
Synonyms	8-Chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-d5; Estazolam (phenyl-d5); Deuteronated Estazolam; Estazolam Internal Standard; Estazolam-d5; 4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine, 8-chloro-6-(phenyl-d5)-; Eurodin-d5
EINECS	Contact for details

Quality Control

Our Estazolam-D5 is manufactured under strict quality systems to ensure the highest standards of purity and isotopic enrichment required for analytical applications. Each batch is rigorously tested using advanced techniques including NMR and High-Resolution Mass Spectrometry (HRMS) to confirm deuteration level and chemical purity. A comprehensive Certificate of Analysis (COA) detailing assay, isotopic purity, and impurity profile is provided with every shipment to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuteration)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.