Description

2-(2,2,2-Trifluoroacetyl)-1,2,3,4-Tetrahydroisoquinoline-6-Sulfonyl Chloride is a high-value, multi-functional chemical building block essential for advanced organic synthesis. Its core value lies in its dual reactivity, featuring both a reactive sulfonyl chloride group and a trifluoroacetyl-protected amine, enabling precise molecular construction. This compound is critically needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, particularly in creating sulfonamide-based molecules and complex heterocyclic scaffolds.

Application

This specialized intermediate is designed for high-value synthesis in research and industrial chemistry. Key application areas include:

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those containing sulfonamide or tetrahydroisoquinoline pharmacophores.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that leverage its unique fluorine-containing structure.
• Chemical Biology & Proteomics: Serves as a reactive handle for labeling, cross-linking, or modifying biomolecules due to the electrophilic sulfonyl chloride group.
• Material Science Research: Employed in the creation of novel polymers or advanced organic materials where the introduction of fluorine atoms or specific heterocycles is desired.
• Custom Synthesis & Contract Manufacturing: A critical building block for fine chemical manufacturers offering bespoke synthesis services to the life sciences industry.

Basic Information

Product Name	2-(2,2,2-Trifluoroacetyl)-1,2,3,4-Tetrahydroisoquinoline-6-Sulfonyl Chloride
CAS No.	169949-39-7
Molecular Formula	C11H9ClF3NO3S
Molecular Weight	327.71 g/mol
Synonyms	6-(Chlorosulfonyl)-1,2,3,4-tetrahydro-2-(2,2,2-trifluoroacetyl)isoquinoline; 1,2,3,4-Tetrahydro-2-(trifluoroacetyl)-6-isoquinolinesulfonyl chloride; 2-(Trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonyl chloride; 6-Isoquinolinesulfonyl chloride, 1,2,3,4-tetrahydro-2-(trifluoroacetyl)-; TAI-6-SC; TFATIQ-SC.
EINECS	Contact for details

Quality Control

Our production of 2-(2,2,2-Trifluoroacetyl)-1,2,3,4-Tetrahydroisoquinoline-6-Sulfonyl Chloride adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure consistency and reliability for your critical syntheses. A detailed Certificate of Analysis (COA) is provided with each shipment, and we support compliance with relevant regulatory frameworks for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C (refrigerated).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.