Description

D-[3-2H]Ribose is a stable isotope-labeled derivative of the essential pentose sugar, D-ribose, specifically deuterated at the 3-position. This compound is a critical tool for advanced research, enabling precise metabolic tracing and structural elucidation in biochemical and pharmaceutical studies. It is primarily utilized by researchers and manufacturers in the fields of nucleic acid chemistry, metabolic pathway analysis, and the development of labeled pharmaceuticals and diagnostics.

Application

• Metabolic Flux Analysis (MFA): Used as a deuterium-labeled tracer to study the pentose phosphate pathway and nucleotide biosynthesis in cell cultures and model organisms.
• NMR Spectroscopy: Serves as an internal standard or a probe for investigating molecular structure, dynamics, and interactions in solution-state NMR studies.
• Mass Spectrometry (MS): Employed as a stable isotope-labeled internal standard for the accurate quantification of D-ribose and its metabolites via LC-MS or GC-MS methods.
• Pharmaceutical Research: Integral in the synthesis of deuterated drug candidates, where deuterium incorporation can alter pharmacokinetic profiles (deuterated drugs).
• Biochemical Research: A key precursor for the synthesis of labeled nucleosides, nucleotides, and nucleic acids for mechanistic and structural studies.
• Diagnostic Agent Development: Potential use in creating labeled probes or contrast agents for advanced medical imaging techniques.

Basic Information

Item	Detail
Product Name	D-[3-2H]Ribose
CAS No.	169783-76-0
Molecular Formula	C5H92H O5
Molecular Weight	151.13 g/mol (for C5H9DO5)
Synonyms	3-Deutero-D-ribose; D-Ribose-3-d; (3R)-3-Deuterio-D-ribose; 3-Deutero-D-ribofuranose; Deuterated D-ribose; [3-2H]-D-Ribose; D-Ribose (3-deutero); Stable Isotope Labeled D-ribose
EINECS	Contact for details

Quality Control

Every batch of our D-[3-2H]Ribose is produced and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity, with comprehensive testing including NMR for isotopic enrichment, HPLC for chemical purity, and specific optical rotation. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with each order to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % 2H
Specific Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.