Description

(As)-6-Chloro-5-Fluoro-α-Methyl-1H-Indole-1-Ethanamine Fumarate is a high-purity, non-racemic chiral indole derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in providing a structurally defined, enantiomerically pure building block essential for the efficient synthesis of complex active pharmaceutical ingredients (APIs). This compound is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel drug candidates.
• CNS Drug Discovery: Building block for potential serotonin receptor modulators and other neuroactive compounds.
• Oncology Research: Used in the synthesis of targeted small-molecule inhibitors and other anti-cancer agents.
• Asymmetric Synthesis: Serves as a valuable starting material for creating enantiomerically pure compounds in medicinal chemistry.
• Process Chemistry: Employed in route scouting and scale-up studies for API manufacturing.
• Reference Standard: Used as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(As)-6-Chloro-5-Fluoro-α-Methyl-1H-Indole-1-Ethanamine Fumarate
CAS No.	169675-09-6
Molecular Formula	C15H16ClFN2O4
Molecular Weight	342.75 g/mol
Synonyms	(S)-6-Chloro-5-fluoro-α-methyl-1H-indole-1-ethanamine fumarate; (S)-1-(1-Aminoethyl)-6-chloro-5-fluoroindole fumarate; 6-Chloro-5-fluoro-α-methyl-1H-indole-1-ethanamine (S)-fumarate; (S)-6-Chloro-5-fluoro-α-methylindole-1-ethylamine fumarate salt; (1S)-1-(6-Chloro-5-fluoro-1H-indol-1-yl)ethan-1-amine fumarate; Fumaric acid salt of (S)-6-chloro-5-fluoro-α-methyl-1H-indole-1-ethanamine
EINECS	Contact for details

Quality Control

Our (As)-6-Chloro-5-Fluoro-α-Methyl-1H-Indole-1-Ethanamine Fumarate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.