Description

5,6-Difluoro-2-Indole Carboxylic Acid Ether Ester is a high-value fluorinated indole derivative, a crucial synthetic intermediate in modern organic chemistry. Its core value lies in its role as a versatile building block for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and advanced materials. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require precise fluorination to modulate the biological activity, metabolic stability, and physicochemical properties of their target compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially kinase inhibitors, receptor antagonists, and other small-molecule therapeutics where the difluoroindole scaffold is pharmacologically relevant.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and pesticides, leveraging fluorine atoms to enhance bioavailability and environmental stability.
• Material Science: Serves as a monomer or functional additive in the creation of specialty polymers, liquid crystals, and organic electronic materials due to its conjugated indole system and fluorine substituents.
• Chemical Synthesis: A versatile building block for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) and other transformations to create diverse indole-based compound libraries for screening.
• Biochemical Tool Compound: Utilized in academic and industrial research to probe biological pathways and enzyme functions as a labeled or modified chemical probe.

Basic Information

Product Name	5,6-Difluoro-2-Indole Carboxylic Acid Ether Ester
CAS No.	169674-34-4
Molecular Formula	C12H9F2NO2
Molecular Weight	237.20 g/mol
Synonyms	5,6-Difluoro-1H-indole-2-carboxylic acid ester; Ethyl 5,6-difluoro-1H-indole-2-carboxylate (common example); 2-Carbethoxy-5,6-difluoroindole; 5,6-Difluoroindole-2-carboxylic acid ethyl ester; 1H-Indole-2-carboxylic acid, 5,6-difluoro-, ethyl ester; DFICE; 169674-34-4
EINECS	Contact for details

Quality Control

Our 5,6-Difluoro-2-Indole Carboxylic Acid Ether Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures material consistency and reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.