Description

6-Chloro-5-Fluoro-1H-Indole-2-Carboxylic Acid Ethyl Ester is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core value lies in its indole scaffold, which is strategically functionalized with chloro and fluoro substituents, making it a critical intermediate for constructing complex molecules with targeted biological activity. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in oncology, CNS disorders, and anti-inflammatory research.
• Agrochemical Synthesis: Used to build advanced active ingredients for crop protection products, leveraging the bioactivity of the halogenated indole core.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry, enabling structure-activity relationship (SAR) studies and library synthesis.
• Material Science Precursor: Potential use in the development of specialty chemicals and advanced organic materials.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	6-Chloro-5-Fluoro-1H-Indole-2-Carboxylic Acid Ethyl Ester
CAS No.	169674-00-4
Molecular Formula	C11H9ClFNO2
Molecular Weight	241.65 g/mol
Synonyms	Ethyl 6-Chloro-5-fluoro-1H-indole-2-carboxylate; 6-Chloro-5-fluoroindole-2-carboxylic acid ethyl ester; 1H-Indole-2-carboxylic acid, 6-chloro-5-fluoro-, ethyl ester; 169674-00-4; 6-Chloro-5-fluoro-1H-indole-2-carboxylic acid ethyl ester; Ethyl 6-chloro-5-fluoroindole-2-carboxylate; 6-Chloro-5-fluoro-2-indolecarboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our 6-Chloro-5-Fluoro-1H-Indole-2-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.