Description

3-Azabicyclo[3.1.0]Hexan-2-One, (1R)- is a high-value, chiral bicyclic lactam building block of significant interest in advanced organic synthesis. Its unique constrained scaffold and defined stereochemistry make it a critical intermediate for constructing complex molecular architectures with precise three-dimensional control. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of central nervous system (CNS) drugs, enzyme inhibitors, and other therapeutic agents requiring rigid, stereodefined frameworks.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where its bicyclic structure can impart specific biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to induce high enantioselectivity.
• Peptidomimetics and Bioisosteres: The lactam moiety is utilized to replace peptide bonds, creating more metabolically stable analogs in medicinal chemistry programs.
• Material Science Research: Investigated as a monomer or building block for novel polymers with specific thermal or mechanical properties derived from its strained ring system.
• Academic and R&D Laboratories: Employed in methodological studies and the exploration of new synthetic routes involving strained heterocycles.

Basic Information

Product Name	3-Azabicyclo[3.1.0]Hexan-2-One, (1R)-
CAS No.	169532-12-1
Molecular Formula	C6H9NO
Molecular Weight	111.14 g/mol
Synonyms	(1R)-3-Azabicyclo[3.1.0]hexan-2-one; (1R)-2-Oxo-3-azabicyclo[3.1.0]hexane; (R)-3-Azabicyclo[3.1.0]hexan-2-one; (R)-2-Oxo-3-azabicyclo[3.1.0]hexane; (1R,5S)-3-Azabicyclo[3.1.0]hexan-2-one; (1R)-Hexahydro-1H-pyrrolo[1,2-c]oxazol-3-one; (R)-Bicyclic Lactam; (R)-Constrained Proline Lactam Derivative
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to guarantee identity, purity, and chiral integrity. Certificates of Analysis (COA) are available upon request, detailing specifications such as chiral purity (enantiomeric excess), chemical purity by HPLC, and residual solvent content. We adhere to cGMP principles for production where applicable to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.