Description

(S)-Gna-T-Phosphoramidite is a high-purity, chiral phosphoramidite monomer essential for the automated synthesis of oligonucleotides. This compound matters for its critical role in constructing sophisticated nucleic acid analogs, enabling precise control over stereochemistry in the final product. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of antisense oligonucleotides, siRNA therapeutics, and other advanced nucleic acid-based drugs, where sequence fidelity and stereochemical purity are paramount.

Application

• Solid-Phase Oligonucleotide Synthesis: As a key building block in automated synthesizers for the introduction of modified nucleoside units.
• Antisense Oligonucleotide (ASO) Development: For the production of stereochemically defined ASOs with enhanced stability and binding affinity.
• siRNA and miRNA Therapeutics: In the synthesis of RNA strands where specific chirality at the phosphorus center is required for optimal biological activity and nuclease resistance.
• Phosphorothioate Backbone Modification: Serving as a precursor in the synthesis of oligonucleotides with chiral phosphorothioate linkages.
• Diagnostic Probe Synthesis: For creating high-specificity labeled probes used in genomic testing and molecular diagnostics.
• Academic & Industrial R&D: In exploratory chemistry for developing novel nucleotide analogs and studying structure-activity relationships.

Basic Information

Product Name	(S)-Gna-T-Phosphoramidite
CAS No.	168332-13-6
Molecular Formula	C41H49N4O7P
Molecular Weight	740.83 g/mol
Synonyms	(S)-GNA-T-Phosphoramidite; 1-[(2R,3R,4R,5R)-5-[Bis(4-methoxyphenyl)-phenylmethoxy]methyl-4-[(tert-butyldimethylsilyl)oxy]-3-[(2-cyanoethoxy)-(diisopropylamino)phosphanyl]oxyoxolan-2-yl]-5-methyl-pyrimidine-2,4-dione; GNA Thymidine Phosphoramidite (S-isomer); (S)-Glycerol Nucleic Acid T-Phosphoramidite; (S)-GNA-T Amidite; GNA monomer S-configuration; Thymidine GNA phosphoramidite (S-form)
EINECS	Contact for details

Quality Control

Our (S)-Gna-T-Phosphoramidite is manufactured under strict quality systems to ensure batch-to-batch consistency for critical research and GMP-grade applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and chiral integrity. We adhere to stringent internal specifications, with testing methodologies including HPLC, NMR, and mass spectrometry to confirm high chemical and stereochemical purity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a dry, cool place. This material is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures will lead to decomposition and reduced coupling efficiency.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% (S-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.