Description

Ethyl 5-Fluoro-3-Iodo-1H-Indole-2-Carboxylate is a high-value, multi-functional indole derivative serving as a critical synthetic intermediate in advanced organic chemistry. Its molecular architecture, featuring both fluorine and iodine substituents, makes it an indispensable building block for constructing complex heterocyclic frameworks. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where precise molecular modification is paramount.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potent drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory pathways.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and plant growth regulators that require halogenated indole cores for enhanced bioactivity.
• Material Science: Serves as a monomer or functionalizing agent in the creation of specialty polymers and organic electronic materials with unique optoelectronic properties.
• Chemical Biology & Proteomics: Employed as a molecular probe or a tagging reagent for studying protein-ligand interactions and enzyme mechanisms.
• Academic & Contract Research: Essential for methodological development in organic synthesis, including cross-coupling reactions and heterocycle construction.

Basic Information

Product Name	Ethyl 5-Fluoro-3-Iodo-1H-Indole-2-Carboxylate
CAS No.	167631-21-2
Molecular Formula	C11H9FINO2
Molecular Weight	333.10 g/mol
Synonyms	5-Fluoro-3-iodo-1H-indole-2-carboxylic acid ethyl ester; Ethyl 5-fluoro-3-iodoindole-2-carboxylate; 1H-Indole-2-carboxylic acid, 5-fluoro-3-iodo-, ethyl ester; 2-Carbethoxy-5-fluoro-3-iodoindole; 5-Fluoro-3-iodoindole-2-carboxylic acid ethyl ester; 167631-21-2; Ethyl 5-fluoro-3-iodo-1H-indole-2-carboxylate
EINECS	Contact for details

Quality Control

Our Ethyl 5-Fluoro-3-Iodo-1H-Indole-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, which includes data from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.