Description

3-Azabicyclo[3.1.0]Hexane-2,3-Dicarboxylic Acid, 3-(1,1-Dimethylethyl) Ester, (1R,2S,5S)- is a high-purity, chiral bicyclic amino acid derivative serving as a critical advanced pharmaceutical intermediate (API). Its unique, constrained three-dimensional structure makes it an invaluable building block for medicinal chemists designing novel therapeutic agents. This compound is primarily sought by pharmaceutical R&D and fine chemical synthesis teams for the development of complex, bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Asymmetric Synthesis: Used as a rigid, stereodefined scaffold to induce chirality in the construction of novel chemical entities.
• Protease Inhibitor Development: Employed in the research and synthesis of inhibitors targeting specific enzymes.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands used in asymmetric catalysis.
• Chemical Biology Probes: Utilized in the design of molecular probes to study biological pathways and protein function.
• Academic & Industrial Research: A valuable reagent for methodological development and exploration of new chemical space in organic chemistry.

Basic Information

Product Name	3-Azabicyclo[3.1.0]Hexane-2,3-Dicarboxylic Acid, 3-(1,1-Dimethylethyl) Ester, (1R,2S,5S)-
CAS No.	167611-99-6
Molecular Formula	C12H19NO4
Molecular Weight	241.28 g/mol
Synonyms	(1R,2S,5S)-3-(tert-Butyl) 3-azabicyclo[3.1.0]hexane-2,3-dicarboxylate; (1R,2S,5S)-3-(tert-Butoxycarbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxylic acid; (1R,2S,5S)-2-Carboxy-3-azabicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester; tert-Butyl (1R,2S,5S)-2-carboxy-3-azabicyclo[3.1.0]hexane-3-carboxylate; Bicyclic Proline Derivative; Chiral Azabicyclohexane Ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for research and development. Quality is verified through comprehensive analytical techniques including HPLC, chiral analysis, and NMR to confirm identity, purity, and enantiomeric excess. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.