Description

(E)-4-(2-(5,6,7,8-Tetrahydro-3,5,5,8,8-Pentamethyl-2-Naphthyl)Propen-1 -Yl)-2-Thiophenecarboxylic Acid is a high-purity synthetic intermediate of significant interest in advanced pharmaceutical research and development. This compound matters for its role as a key building block in the synthesis of novel therapeutic agents, particularly those targeting nuclear receptors. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries working on innovative drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel Retinoid X Receptor (RXR) agonists and other nuclear receptor modulators for therapeutic applications.
• Drug Discovery Research: Used as a scaffold or building block in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry Development: Serves as a key starting material (KSM) or advanced intermediate in the scale-up and optimization of active pharmaceutical ingredient (API) manufacturing processes.
• Biochemical Research: Employed in academic and industrial labs to study ligand-receptor interactions and signaling pathways involving retinoid receptors.
• Fine Chemical Synthesis: Utilized for the custom synthesis of complex, high-value organic molecules with specific stereochemical and functional group requirements.

Basic Information

Item	Details
Product Name	(E)-4-(2-(5,6,7,8-Tetrahydro-3,5,5,8,8-Pentamethyl-2-Naphthyl)Propen-1 -Yl)-2-Thiophenecarboxylic Acid
CAS No.	167413-66-3
Molecular Formula	C23H28O2S
Molecular Weight	368.53 g/mol
Synonyms	4-[(1E)-2-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]-2-thiophenecarboxylic acid; AGN 194204; LG 100754; RXR Agonist LG100754; (E)-LG100754; 2-Thiophenecarboxylic acid, 4-[2-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]-, (E)-; Targretin-related compound
EINECS	Contact for details

Quality Control

Our (E)-4-(2-(5,6,7,8-Tetrahydro-3,5,5,8,8-Pentamethyl-2-Naphthyl)Propen-1 -Yl)-2-Thiophenecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. For long-term storage, consider under inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.