Description

tert-Butyl 7-Hydroxy-6-Methoxy-3,4-Dihydro-1H-Isoquinoline-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant synthetic value. This compound serves as a critical building block in the synthesis of complex bioactive molecules, particularly in medicinal chemistry. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex alkaloids and other pharmacologically active compounds.
• Medicinal Chemistry Research: Used in the research and development (R&D) of new drug candidates, particularly those targeting neurological and cardiovascular pathways.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of active pharmaceutical ingredients (APIs).
• Chemical Synthesis: Serves as a versatile synthon for introducing the tetrahydroisoquinoline scaffold into more complex molecular architectures.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	tert-Butyl 7-Hydroxy-6-Methoxy-3,4-Dihydro-1H-Isoquinoline-2-Carboxylate
CAS No.	167159-80-0
Molecular Formula	C15H21NO4
Molecular Weight	279.33 g/mol
Synonyms	7-Hydroxy-6-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester; tert-Butyl 7-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; 1,2,3,4-Tetrahydro-7-hydroxy-6-methoxyisoquinoline-2-carboxylic acid tert-butyl ester; 2-(tert-Butoxycarbonyl)-7-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline; BOC-7-Hydroxy-6-methoxy-THIQ; 167159-80-0
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-Hydroxy-6-Methoxy-3,4-Dihydro-1H-Isoquinoline-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all specification results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.