Description

4-Bromo-5-Chlorothiophene-2-Sulfonyl Chloride is a high-purity, multi-functional heterocyclic building block and key sulfonylating agent. This compound is critical for the synthesis of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and advanced agrochemicals. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel thiophene-based scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of sulfonamide-based drug candidates, including potential enzyme inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that leverage the thiophene sulfonyl chloride moiety for enhanced bioactivity.
• Material Science Research: Serves as a building block for creating functional polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes (ABPs) for studying enzyme function and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4-Bromo-5-Chlorothiophene-2-Sulfonyl Chloride
CAS No.	166964-35-8
Molecular Formula	C4HBrCl2O2S2
Molecular Weight	300.00 g/mol
Synonyms	2-Thiophenesulfonyl chloride, 4-bromo-5-chloro-; 4-Bromo-5-chloro-2-thiophenesulfonyl chloride; 4-Bromo-5-chlorothiophene-2-sulfonyl chloride; 5-Chloro-4-bromothiophene-2-sulfonyl chloride; 166964-35-8; Thiophene-2-sulfonyl chloride, 4-bromo-5-chloro-; 4-Bromo-5-chloro-thiophene-2-sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 4-Bromo-5-Chlorothiophene-2-Sulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for research and scale-up applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of our global B2B clientele in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.