Description

2-(Bromomethyl)-5-Nitrothiophene is a versatile and highly reactive heterocyclic building block, essential for advanced organic synthesis. Its molecular structure, featuring both an electrophilic bromomethyl group and an electron-withdrawing nitro substituent, makes it a critical intermediate for constructing complex sulfur-containing scaffolds. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of thiophene-based drug candidates, including potential kinase inhibitors and antimicrobial agents.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that incorporate the thiophene moiety for enhanced activity.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of conductive polymers, organic semiconductors, and advanced organic frameworks.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create biaryl and complex conjugated systems.
• Nucleophilic Substitution: The reactive bromomethyl group allows for facile functionalization with various nucleophiles (amines, thiols, alkoxides) to diversify molecular libraries.
• Chemical Research & Development: A valuable tool for academic and industrial R&D in exploring new heterocyclic chemistry and reaction methodologies.

Basic Information

Product Name	2-(Bromomethyl)-5-Nitrothiophene
CAS No.	166887-84-9
Molecular Formula	C5H4BrNO2S
Molecular Weight	222.06 g/mol
Synonyms	5-Nitro-2-(bromomethyl)thiophene; 2-Bromomethyl-5-nitrothiophene; Thiophene, 2-(bromomethyl)-5-nitro-; 5-Nitrothiophene-2-methyl bromide; (5-Nitro-2-thienyl)methyl bromide
EINECS	Contact for details

Quality Control

Our 2-(Bromomethyl)-5-Nitrothiophene is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent performance. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere for prolonged stability. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.