Description

tert-Butyl 6-Cyano-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the dihydroisoquinoline class of compounds. This versatile building block is critical for the synthesis of complex molecules, offering a protected amine and a reactive nitrile group for further functionalization. It is primarily utilized by research institutions and pharmaceutical manufacturers in the development of new active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting the central nervous system.
• Organic Synthesis Building Block: Used in multi-step synthesis for constructing complex heterocyclic frameworks due to its reactive cyano and protected amine functionalities.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies for new therapeutic agents.
• Fine Chemical Production: Serves as a starting material for the manufacture of specialty chemicals and advanced materials.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis projects and scale-up development.

Basic Information

Item	Details
Product Name	tert-Butyl 6-Cyano-3,4-Dihydroisoquinoline-2(1H)-Carboxylate
CAS No.	166398-33-0
Molecular Formula	C15H16N2O2
Molecular Weight	256.30 g/mol
Synonyms	2(1H)-Isoquinolinecarboxylic acid, 6-cyano-3,4-dihydro-, 1,1-dimethylethyl ester; 6-Cyano-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; tert-Butyl 6-cyano-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; Boc-6-cyano-THIQ; 6-Cyano-THIQ-Boc; BOC-6-Cyano-1,2,3,4-tetrahydroisoquinoline; 166398-33-0
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Cyano-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.