Description

(S,S)-2-(2-Amino-3-Methyl-Butyryl)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid Benzyl Ester, Hcl is a high-purity, non-natural amino acid derivative and a key chiral building block in advanced organic synthesis. This compound is critical for researchers and manufacturers requiring precise stereochemistry and high chemical fidelity in complex molecular architectures. It is primarily utilized in the development of novel pharmaceutical intermediates, peptide mimetics, and bioactive compounds, serving the needs of the global life sciences and fine chemical industries.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in peptide-based drug discovery.
• Peptidomimetic Synthesis: Used to construct constrained peptide analogs and mimetics that enhance metabolic stability and bioavailability in therapeutic candidates.
• Chemical Biology Research: Serves as a specialized building block for probing enzyme-substrate interactions and designing enzyme inhibitors.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in stereoselective synthesis to introduce complex chiral centers.
• Process Development: Used in scaling up synthetic routes for novel compounds in pilot plants and commercial manufacturing.

Basic Information

Product Name	(S,S)-2-(2-Amino-3-Methyl-Butyryl)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid Benzyl Ester, Hcl
CAS No.	166169-15-9
Molecular Formula	C22H27ClN2O4
Molecular Weight	418.91 g/mol
Synonyms	(S,S)-2-(2-Amino-3-methylbutyryl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid benzyl ester hydrochloride; Benzyl (3S)-2-[(2S)-2-amino-3-methylbutanoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride; (S,S)-ATIQ-CBz HCl; (S,S)-2-(2-Amino-3-methylbutyryl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid phenylmethyl ester hydrochloride; (3S)-2-[(2S)-2-Amino-3-methyl-1-oxobutyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid benzyl ester hydrochloride; Chiral Tetrahydroisoquinoline Derivative; Boc-D-Val-Tic-OBzl HCl (related precursor); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR). A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We support compliance needs for cGMP environments and can tailor quality documentation upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.