Description

tert-Butyl 5-Nitro-1H-Indole-1-Carboxylate is a protected indole derivative that serves as a versatile and critical building block in advanced organic synthesis. Its primary value lies in providing a reactive nitro-substituted indole scaffold with a Boc-protected nitrogen, enabling selective functionalization for complex molecule construction. This intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of drug candidates, particularly those targeting neurological disorders, inflammation, and oncology.
• Agrochemical Research: Building block for developing novel herbicides, fungicides, and insecticides with indole-based core structures.
• Material Science: Used in the research and development of organic electronic materials and functional dyes.
• Academic & R&D: Serves as a standard reagent in university and corporate research labs for methodological studies in heterocyclic chemistry.
• Peptidomimetics: Employed in the design and synthesis of indole-containing peptide analogs and protease inhibitors.

Basic Information

Product Name	tert-Butyl 5-Nitro-1H-Indole-1-Carboxylate
CAS No.	166104-19-4
Molecular Formula	C13H14N2O4
Molecular Weight	262.26 g/mol
Synonyms	1-Boc-5-nitroindole; 5-Nitro-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester; tert-Butyl 5-nitroindole-1-carboxylate; 1-(tert-Butoxycarbonyl)-5-nitroindole; Boc-5-nitroindole; 5-Nitroindole-1-carboxylic acid tert-butyl ester; 166104-19-4
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Nitro-1H-Indole-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, confirming compliance with customer specifications and internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere for long-term storage. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.