Description

5-(tert-Butoxycarbonyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid is a high-purity, advanced pharmaceutical intermediate featuring a protected amine group and a carboxylic acid functionality. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of platelet aggregation inhibitors and other therapeutic agents. It is an essential building block for research institutions and pharmaceutical manufacturers engaged in drug discovery and process development.

Application

• Key Intermediate in API Synthesis: Primarily used in the multi-step synthesis of clopidogrel and related thienopyridine-class antiplatelet drugs.
• Pharmaceutical R&D: Serves as a crucial scaffold for medicinal chemists exploring new chemical entities and analogs in cardiovascular and neurological research.
• Process Chemistry: Employed in the scale-up and optimization of manufacturing routes for commercial pharmaceutical production.
• Custom Synthesis: Used as a starting material for the preparation of more complex, proprietary molecules in contract research and manufacturing.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in pharmaceutical labs.

Basic Information

Product Name	5-(tert-Butoxycarbonyl)-4,5,6,7-Tetrahydrothieno[3,2-C]Pyridine-2-Carboxylic Acid
CAS No.	165947-48-8
Molecular Formula	C13H17NO4S
Molecular Weight	283.34 g/mol
Synonyms	5-((tert-Butoxycarbonyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid; 2-Thiophenecarboxylic acid, 4,5,6,7-tetrahydro-5-[[(1,1-dimethylethoxy)carbonyl]amino]thieno[3,2-c]pyridine-; BOC-thienopyridine-2-carboxylic acid; Clopidogrel intermediate; tert-Butyl 2-carboxythieno[3,2-c]pyridine-5(4H,6H,7H)-carboxylate (tautomeric form); 5-Boc-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 5-(tert-Butoxycarbonyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP guidelines suitable for pharmaceutical intermediate applications, ensuring reliable supply and traceability for your critical R&D and manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if possible to maximize shelf-life stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.