Description

(R)-4-(2-Iodo-Ethyl)-2,2-Dimethyl-[1,3]Dioxolane is a chiral, iodinated dioxolane derivative, a crucial protected form of a chiral iodohydrin synthon. This compound matters as a versatile and stereochemically defined building block for the synthesis of complex molecules, enabling the introduction of iodine and subsequent functional group transformations. It is primarily needed by pharmaceutical and fine chemical research organizations for applications in asymmetric synthesis, medicinal chemistry, and the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral precursor in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Used as a stereodefined electrophile or nucleophile in stereoselective carbon-carbon and carbon-heteroatom bond-forming reactions.
• Medicinal Chemistry & Drug Discovery: Employed in structure-activity relationship (SAR) studies and the construction of chiral scaffolds for biological evaluation.
• Fine Chemical Production: Serves as a specialized intermediate for manufacturing high-value agrochemicals, flavors, and fragrances.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) due to the reactive iodoethyl moiety.
• Chiral Auxiliary/Protecting Group Chemistry: The dioxolane group protects a diol or carbonyl, while the iodine allows for further functionalization, making it a bifunctional synthon.

Basic Information

Product Name	(R)-4-(2-Iodo-Ethyl)-2,2-Dimethyl-[1,3]Dioxolane
CAS No.	165657-74-9
Molecular Formula	C7H13IO2
Molecular Weight	256.08 g/mol
Synonyms	(R)-4-(2-Iodoethyl)-2,2-dimethyldioxolane; (R)-4-(2-Iodoethyl)-2,2-dimethyl-1,3-dioxolane; (R)-2,2-Dimethyl-4-(2-iodoethyl)-1,3-dioxolane; (R)-1,2-O-Isopropylidene-4-iodo-1,2-butanediol; (R)-1,2-O-Isopropylidene-1,2,4-butanetriol 4-iodide; (R)-4-Iodobutane-1,2-diol 1,2-acetonide; (R)-Glycerol Acetonide Iodide Derivative
EINECS	Contact for details

Quality Control

Our (R)-4-(2-Iodo-Ethyl)-2,2-Dimethyl-[1,3]Dioxolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting standards for research and development use. A comprehensive Certificate of Analysis (COA) detailing identity, purity (assay), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C for long-term stability. Allow the container to reach room temperature before opening to minimize moisture ingress. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.