Description

6-(Trifluoromethyl)Benzo[B]Thiophen-3-Amine is a high-value, fluorinated heterocyclic building block essential for advanced organic synthesis. Its core value lies in the unique combination of the electron-withdrawing trifluoromethyl group and the versatile benzo[b]thiophene scaffold, enabling precise modulation of electronic and steric properties in target molecules. This compound is critically needed by R&D and process development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the CF3 group improves lipophilicity and biological activity.
• Material Science Precursor: Serves as a building block for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: An important compound for academic and industrial research focused on incorporating fluorinated motifs into complex molecules.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	6-(Trifluoromethyl)Benzo[B]Thiophen-3-Amine
CAS No.	165108-01-0
Molecular Formula	C9H6F3NS
Molecular Weight	217.21 g/mol
Synonyms	3-Amino-6-(trifluoromethyl)benzo[b]thiophene; 6-(Trifluoromethyl)-1-benzothiophen-3-amine; 6-Trifluoromethyl-1-benzothiophen-3-ylamine; 6-Trifluoromethylbenzo[b]thiophen-3-amine; Benzo[b]thiophen-3-amine, 6-(trifluoromethyl)-; 3-Amino-6-trifluoromethylbenzothiophene
EINECS	Contact for details

Quality Control

Every batch of 6-(Trifluoromethyl)Benzo[B]Thiophen-3-Amine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, and NMR is supplied with each shipment. Our quality commitment supports compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive nature and propensity to be easily oxidized (store under inert atmosphere), it is recommended to handle under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize headspace in opened containers.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.